侧脑室内注射3,4-二羟基苯甲醛对大鼠肺动脉压和体动脉压的影响

Effect of intracerebro-ventricular injection of salvial miltiorrhijae on polmonary arterial pressure and body arterial pressure in rats

探讨 3,4 二羟基苯甲醛降低大鼠肺动脉压 (PPA)和体动脉压 (PBA)的作用及机制。以PPA和PBA为指标 ,在氨基甲酸乙酯麻醉、三碘季胺酚制动、呼吸机控制呼吸的SD大鼠上观察 3,4 二羟基苯甲醛对大鼠PPA和PBA的影响 ,连续观察 30minPPA和PBA曲线变化 ,并与对照组和生理盐水组比较。给药后大鼠PPA和PBA明显降低 ,其中PPA在 10～ 15min达最低值 ,PBA在 5～ 10min降至最低值 ,与对照组和生理盐水组比较差异显著 (P <0 0 1)。 3,4 二羟基苯甲醛有明显降低大鼠PPA和PBA的作用。侧脑室预先注射 β 受体阻断剂普萘洛尔可部分阻断 3,4 二羟基苯甲醛的降压效应。推测 3,4 二羟基苯甲醛降低PPA和PBA的作用可能部分由脑内 β 受体所介导。

Intracerebro-ventricular injection of salvial miltionrrhijae(SM) was carried out to asses the changes of pulmonary pressure (PPA) and body arterial pressure (PBA) in rats. After SM injection, the rats PPA and PBA dropped significantly and reached the lowest point respectively in 10 and 5 minutes. Compared with the control group and the NS group, both pressures have marked difference (P<0.01). SM has a significant effect on the decrease of rats pulmonary arterial pressure and body arterial pressure. Intracerebro-ventricular injection of β-receptor blocking agents propranolol in advance can partly inhibit SM's function to decrease pulmonary arterial pressure and body arterial pressure. Therefore, it is suggested that SM's effect on the reduction of pulmonary arterial pressure and body arterial pressure may be medicted by introcerebral β-receptor.