六味地黄超微细粉药理学研究

Study on Pharmacology of Ultra-fine Particles Compound Rehmannia

目的 :观察六味地黄超微细粉药理作用与传统加工六味地黄细粉的差异。方法 :急性毒性死亡率法估算药动学参数 ;抗疲劳、降糖、碳粒廓清、耐缺氧及溶血素生成实验测定药理活性。结果 :超微细粉急性毒性量效关系明显 ;抗疲劳、降糖、碳粒廓清、耐缺氧及溶血素生成作用约与传统加工细粉 3倍量相当。结论 :超微细粉在生物利用度及药理活性方面均优于传统加工细粉 ,可以提高疗效。

Objective: To observe pharmacological difference between ultra fine particles of six ingredient Rehmannia pill and traditional six ingredient Rehmannia pill. Method: Pharmacokinetic index was measured by death rate, and pharmacology actions were compared by anti fatigue, hypoglycemic,clearance rate of charcoal particle, hypoxia resistance and serum hemolysin concentration experiment. Result: Dose effection was significant and pharmacology actions were more than traditional six ingredient Rehmannia pill in six ingredient Rehmannia pill. Conclusion: Ultra fine particles of six ingredient Rehmannia pill are better than traditional six ingredient Rehmannia pill in bioavailability and pharmacology actions, and the weight of pill is reduced while efficacy is enhenced by ultra fine particles .