止痛涂膜药理作用研究

Study of pharmacological effect of analgesic pigmentum

目的 研究止痛涂膜的药理作用。方法 采用小白鼠热板法、醋酸扭体法和小白鼠甩尾法观察镇痛作用 ;采用巴豆油致小白鼠耳肿胀和角叉菜胶致大鼠足关节肿胀实验观察抗炎作用 ;采用皮肤刺激、皮肤过敏等实验观察皮肤用药毒性。结果 止痛涂膜对以上镇痛和抗炎模型均有明显的抑制作用 ,与对照组比较均有显著差异性 (P <0 .0 5～ 0 .0 0 1 ) ,对家兔皮肤无毒、无刺激 ,对豚鼠无致敏作用。结论 止痛涂膜具有镇痛、抗炎作用 ,皮肤用药安全。

Objective To investigate the pharmacological effect of analgesic pigmentum. Methods The analgesic effects were observed by means of mouse hot plate, acetic acid twisting body and mouse tail-flick test; anti-inflammatory effects were observed by using croton oil to bring out mice ears to be swollen and using carrageen to result in the swelling of rat's foot joint; and the enepidemic toxicities were observed by skin stimulation and dermal sensitivity test. Results Analgesic pigmentum had obvious analgesic and anti-inflammatory effects to the experimental animal models mentioned above, there were significant differences between experimental group and control group (P<0.05～0.001), without any toxic and stimulative effects to the rabbit's skin and sensitization to cavy. Conclusion Analgesic pigmentum possesses analgesic and anti-inflammatory effects, with safe application on skin.