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蛋白质组学研究及其在肿瘤诊断和治疗中的应用 被引量：3

Proteomics and application in tumor diagnosis and treatment
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摘要 蛋白质组学是研究蛋白质组成和动态变化的一门新兴学科 ,蛋白质组学研究技术的主要步骤包括样品制备、双向凝胶电泳 (2 DE)、蛋白质的鉴定技术及相应的信息技术和数据库 4大方面。目前 ,蛋白质组学研究已应用于膀胱癌、乳腺癌、结肠癌、食管癌。
作者 郭俊超
机构地区 中国协和医科大学中国医学科学院北京协和医院普通外科
出处 《国外医学（肿瘤学分册）》 2002年第3期166-168,共3页 Foreign Medical Sciences (Cancer Section)
关键词 蛋白质组学 研究 肿瘤 诊断 治疗
分类号 R730.4 [医药卫生—肿瘤] R730.5 [医药卫生—肿瘤]
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参考文献16

  • 1Le Naour F. Contribution of proteomics to tumor immunology [J]. Proteomics, 2001,1(10):1295-1302.
  • 2Bichsel VE, Liotta LA, Petricoin EF 3rd. Cancer proteomics:from biomarker discovery to signal pathway profiling[J]. Cancer J, 2001,7(1):69-78.
  • 3Pandey A, Mann M. Proteomics to study genes and genomes[J]. Nature, 2000, 405(6788):837-846.
  • 4Banks RE, Dram MJ, Forbes MA, et al. The potential use of/laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis-preliminary findings[J]. Ectrophoresis, 1999, 20(4-5):689-700.
  • 5Shevchenko A, Loboda A, Shevchenko A, et al. MALDI quadruple time-of-flight mass spectrometry: powerful tool for proteomic research[J]. Anal Chem, 2000, 72(9):2132-2141.
  • 6Celis JE, Ostergaard M, Jensen NA, et al. Human and mouse proteomic databases: novel resources in the protein universe [J]. FEBS Lett, 1998, 430(1-2):64-72.
  • 7Celis JE, Wolf H, Ostergaard M. Bladder squamous cell carcinoma biomarkers derived from proteomics [J]. Electrophoresis, 2000, 21(11):2115-2121.
  • 8Vlahou A, Schellhammer PF, Mendrinos S, et at. Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine[J]. Am J Pathol, 2001, 158(4):1491-1502.
  • 9Paweletz CP, Liotta LA, Petricoin EF 3rd. New technologies for biomarker analysis of prostate cancer progression: Laser capture microdissection and tissue proteomics[J]. Urology, 2001,57(4 Suppl l ):160-163.
  • 10Alaiya AA, Franzen B, Auer G, et al. Cancer proteomics: from identifieation of novel markers to creation of artificial learning models for tumor classification[J]. Electrophoresis, 2000, 21 (6) : 1210-1217.

同被引文献29

  • 1Aul C, Giagounidis A, Germing U. Epidemiologieal featuresof myelodysplastic syndromes: results from regional cancersurveys and hospital-based statistics [ J ]. Int J Hematol, 2001, 73(4): 405-10.
  • 2Ma X, Does M, Raza A, et al. Myelodysplastic syndromes: incidence and survival in the United States[J]. Cancer. 2007, 109(8): 1536-42.
  • 3Nolte F, Hotinann WK. Myelodysplastie syndromes: molecular pathogenesis and genomic changes [ J ]. Ann Hematol, 2008, 87( 10): 777-95.
  • 4Mano H. DNA micro-array analysis ofmyelodysplastic syndrome [ J ]. Leuk Lymphoma, 2006, 47(1): 9-14.
  • 5Rajcevic U, Niclou SP, Jimenez CR. Proteomics strategies for target identification and biomarker discovery in cancer [J ]. Front Biosci, 2009, 14! 3292-303.
  • 6Vardiman JW, Harris NL, Brtnming RD. The World Health Organization (WHO) classification of the myeloid neoplasms [J]. Blood, 2002, 100(7): 2292-302.
  • 7Meyers CA, Albitar M, Estey E. Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome [ J ]. Cancer, 2005, 104(4): 788-93.
  • 8Hsu HC, Lee YM, Tsai WH, et aL Circulating levels ofthrombopoietic and inflammatory cytokines in patients with acute myeloblastic leukemia and myelodysplastic syndrome [J]. Ontology, 2002, 63 (1): 64-9.
  • 9Alexandrakis MG, Passam FH, Pappa CA, et al. Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with hone marrow microvascular density [ J ]. Int J Immunopathol Pharmacol, 2005, 18(2): 287-95.
  • 10Pro B, Dang NH. CD26/dipeptidyl peptidase IV and its role in cancer [J]. Histol Histopathol. 2004, 19(4): 1345-51.

引证文献3

二级引证文献11

国外医学（肿瘤学分册）
2002年 第3期

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