期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

非甾体类抗炎药对胃肠道恶性肿瘤的化学预防 被引量：8

The development in the chemoprevention of gastrointestinal cancers by NSAID
下载PDF
导出
摘要 近年来研究表明非甾体类抗炎药 (NSAID)能抑制胃肠道肿瘤的发生和发展。长期规律服用NSAID能够显著降低胃肠道恶性肿瘤的发生率和死亡率。本文主要综述NSAID经不同途径的抑癌机制及其对结肠癌、胃癌的化学预防前景。
作者 杨蕾 高歌
机构地区 吉林大学中日联谊医院消化内科
出处 《国外医学（肿瘤学分册）》 CAS 2002年第3期221-224,共4页 Foreign Medical Sciences (Cancer Section)
关键词 非甾体类抗炎药 胃肠道恶性肿瘤 化学预防
分类号 R735 [医药卫生—肿瘤] R730.53 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1Sjodahl R . Nonsteroidal anti-inflammatory drugs and the gastrointestinal. Extent , mode , and dose dependence of anticancer effects [J] . Am J Med, 2001 , 110(1 suppl 1 ):S66-S69.
  • 2Chen WS, Wei SJ , Liu J M, et al . Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2- selective inhibitor, etodolac [J]. Int J Cancer, 2001 , 91 (6):894-899.
  • 3Tomozawa S, Tsuno NH, Sunami E, et al. Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer [J]. Br J Cancer, 2000 , 83(3):324-328.
  • 4Masanaga R, Kohno H ,Dhar DK,et al. Cyclooxygenase-2 expression correlates with tumor neovaseularization and prognosis in human colorectal carcinoma patients [J]. Clin Cancer Res , 2000, 6(10):4064-4068.
  • 5DuBois RN. New paradigms for cancer prevention [J] . Carcinogenesis ,2001 , 22 (5):691-692.
  • 6Bertagnolli MM. Cyclooxygenase-2 as a target for prevention of colorectal cancer [J] . Curr Oncol Rep , 1999,1 (2):173-178.
  • 7Prescott SM, Fitzpatrick FA. Cyclooxygenase-2 and carcinogenesis [J]. Biochim Biophys Acta ,2000,1470(2):M69-78.
  • 8Brown WA, Skinner SA, Malcontenti Wilson C, et al . Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase-1 or cyclooxygenase-2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation[J]. Gut, 2001,48(5):660-666.
  • 9Shureiqi I , Chen D, Lotan R, et al. 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells [J]. Cancer Res , 2000 , 60(24):6846-6850.
  • 10Sasai H, Masaki M, Wakitani K . Suppression of polypogenesis in a new mouse strain with a truncated APC(Delta474) by a novel COX-2 inhibitor ,JTE-522 [J ]. Carcinogenesis , 2000 , 21(5):953-958.

同被引文献57

引证文献8

二级引证文献45

国外医学（肿瘤学分册）
2002年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部