摘要
目的 观察双环醇对缺血 再灌注诱发肾损伤的保护作用。方法 在大鼠肾动脉缺血 再灌注模型上观察双环醇对肾缺血 再灌注引起的血清丙二醛 (MDA)、尿素氮 (BUN) ,肾脏还原型谷胱甘肽 (GSH)、谷胱甘肽巯基转移酶 (GST)及肾线粒体膜流动性改变的影响。结果 双环醇ig 5 0及 2 0 0mg·kg- 1 可剂量依赖性保护缺血 再灌注引起的血清MDA及BUN升高、肾GSH含量降低 ,同时可诱导GST活性 ,缓解由于缺血 再灌注损伤引起的线粒体膜流动性降低。结论 双环醇对肾缺血
AIM To investigate the protective effect of bicyclol on kidney injury induced by ischemia reperfusion in rats. METHODS Bicyclol was orally administered to rats at doses of 50 and 200 mg·kg -1 before ischemia reperfusion injury to evaluate the influence of bicyclol on the formation of MDA and BUN in serum, the content of GSH and the activity of GST in kidney, as well as kidney mitochondria membrane fluidity in ischaemia reperfusion rats. RESULTS Bicyclol given orally at doses of 50 and 200 mg·kg -1 was shown to significantly decrease the increment of MDA and BUN in serum and protect the GSH depletion in kidney. Bicyclol was also shown to induce kidney GST and ameliorate the decrease of mitochondria membrane fluidity. The protective effects of bicyclol on kidney injury induced by ischemia reperfusion are dose dependent. CONCLUSION The protective action of bicyclol on kidney injury induced by ischemia reperfusion may be attributed to its induction of kidney GSH and the GST, stabilization on mitochondria membrane and the inhibition on lipid peroxidation.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第6期412-414,共3页
Acta Pharmaceutica Sinica
