摘要
目的 比较水溶性聚合物的角膜滞留能力 ,评价溶液粘度对其角膜滞留时间的影响 ,为眼用液体制剂的处方设计提供参考。方法 用束缚泡技术 ,以接触角的连续变化为指征 ,在模拟生理条件下考察聚合物从离体眼球表面解吸附的动力学过程。结果 卡波姆、透明质酸钠 (HA)、羟丙基甲基纤维素、聚乙烯醇和羧甲基纤维素钠 (CMC Na)的角膜滞留能力有显著差异 ,其中卡波姆和HA吸附于离体眼球表面达 15min以上 ,显示出较好的生物粘附性。溶液粘度由 12mPa·s增大至 5 0mPa·s,卡波姆和HA的角膜滞留时间分别延长 10min和 7min ,而CMC Na的角膜滞留时间未受影响。结论 体外实验结果表明 ,适当提高溶液粘度能够延长生物粘附性聚合物在角膜表面的滞留时间。
AIM To evaluate how solution viscosity affects the precorneal residence of five water soluble polymers with different properties. METHODS Captive bubble technique was used, with the consecutive change of contact angle interpreted as an indication of desorption process, to study the residence of those polymers in vitro on freshly enucleated rabbit eyes under physiological conditions. RESULTS Carbopol and sodium hyaluronate (HA), which adsorbed to isolated ocular surface more than 15 min, showed the optimum precorneal retentive capabilities. When the solution viscosity increased from 12 mPa·s to 50 mPa·s, the residence time of carbopol and HA were prolonged 10 min and 7 min, respectively, but that of sodium carboxymethylcellulose was not affected. CONCLUSION The result suggested that higher viscosity is beneficial to improve the ocular residence time of bio adhesive polymers.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第6期469-472,共4页
Acta Pharmaceutica Sinica
关键词
水溶性聚合物
角膜滞留
溶液粘度
接触角
液体制剂
water soluble polymer
precorneal residence
solution viscosity
contact angle
