不同剂量尼卡地平用于术中降压的量效观察

The dose-effect observation of nicardipine with different dose used for depressing blood pressure during operation

目的 观察尼卡地平用于围术期高血压降压的量效关系。方法 5 0例择期全麻手术患者 ,随机分为 5组 ,每组 10例。术中当 SBP≥ 16 0 mm Hg和 (或 ) DBP≥ 95 mm Hg时 ,静脉泵入尼卡地平 ,观察并记录给药前和给药后各不同时点 SBP、DBP和 HR的变化。结果 5组患者给药后 SBP、DBP均明显下降 ,但各组血压降至正常的时间不同 , 组 SBP、DBP均在给药后 6 min, 组为给药后 4 min, 组为 2 min, 组为 2 min, 组为 1min。HR给药前、后变化无差异。

Objective To observe the dose effect of nicardipine used for depressing blood pressure during operation.Methods Fifty patients of selective surgery under general anesthesia were divided into 5 groups including 10 patients respectively at random.When systolic blood pressure(SBP)≥160 mmHg and/or diastolic blood pressure(DBP)≥95 mmHg in operation,nicardipine was infused.The changes of SBP,DBP and HR at different stages were observed and recorded before and after nicardipine was given.Results The SBP?DBP decreased obviously in all groups after nicardipine infused intravenously.But the time of blood pressure decreasing to normal value was different.The time is 6 min in group Ⅰ, 4 min in group Ⅱ, 2 min in group Ⅲ,2 min in group Ⅳ,1 min in group Ⅴ respectively.There was no difference in HR before and after nicardipine infused intravenously.Conclusion The time that nicardipine starts to show effect is related to the doses.