S-LDH和Sβ_2-MG判断白血病患者预后的意义

S-LDH AND Sβ_2-MG IN EVALUATING THE PROGNOSIS OF LEUKEMIA

目的 :研究白血病患者血清乳酸脱氢酶 (S- L DH)和血清 β2 -微球蛋白 (Sβ2 - MG)水平对判断白血病预后的价值。方法 :回顾分析 6 0例白血病患者初诊时 S- L DH和 Sβ2 - MG水平与治疗效果的关系。结果 :白血病患者两个指标均明显高于正常对照组。急性非淋巴细胞白血病 (ANL L)两个指标与急性淋巴细胞白血病 (AL L)无显著性差异 (P >0 .0 5 )。发生中枢神经系统白血病 (CNSL)的患者两个指标均明显高于不发生的患者 (P <0 .0 1)。患者对治疗的反应性随两个指标的增高而降低。结论 :初诊时 ,S- L DH和 Sβ2 - MG水平是白血病有意义的预后指标。联合测定 S- L DH和 Sβ2 -

Objective: To evaluate the prognostic values of serum lactic dehydrogenese (S LDH) and serum beta 2 microglobulin(Sβ 2 MG)in leukemia Methods: Data of 60 first visit leukemia patients were retrospectively analysed Results: The levels of S LDH and Sβ 2 MG of the leukemia patients were significantly higher than those of the control group and same in ANLL and ALL The levels of these serum markers of the CNSL patients were significantly higher than those in patients with un CNSL The patients of elevated levels in these markers had less sensitivity to the treatment Conclusion: For the first visit leukemia patients, the levels of these markers are valuable prognostic factors and the combination of S LDH and Sβ 2 MG are more sensitive