P^(53)、bcl-2蛋白和P-gp的过表达与乳腺癌转移的相关性

THE OVEREXPRESSION OF P^(53), bcl-2 PROTEIN AND P-GLYCOPROTEIN IN BREAST CANCER AND RELATION TO METASTASIS

目的 :研究 P53、bcl- 2蛋白和 P-耐药糖蛋白 (P- gp)表达与乳腺癌局部淋巴结转移的关系。方法 :应用免疫组化 SABC法检测 6 0例乳腺癌组织中 P53、bcl- 2蛋白与 P- gp表达。结果 :乳腺癌组织中 P53阳性率 5 6 .7% (34/ 6 0 ) ;bcl- 2阳性率 6 3.3% (38/6 0 ) ;P- gp阳性率 38.3% (2 3/ 6 0 ) ;P53、P- gp异常表达均与淋巴结转移有关 (P <0 .0 5 ) ;3种蛋白表达均与组织病理类型无关(P >0 .0 5 )。P53过表达与 P- gp过表达呈正相关 (P <0 .0 1)。结论 :p5 3基因突变及多药耐药基因 (mdr- 1)编码产物 P- gp表达增高对乳腺癌转移有一定影响 ,早期进行乳腺癌 P53和 m dr-

Objective: To study the P\+\{53\}, bcl 2 protein and P glycoprotein (P gp ) expression in breast cancer tissues and its relation to lymph nodes metastasis Methods: 60 breast cancer specimens were examined for P\+\{53\}, bcl 2 and P gp by immunohistochemical methods Result: The positive expressions for P\+\{53\}, bcl 2 and P gp were 56 7%, 63 3% and 38 3% respectively A significant correlation was found that both P\+\{53\} and P gp overexpression were related to lymph node metastasis (P<0 05)  There was a positive correlation between P\+\{53\} and P gp expression (P=0 003 4)  Conclusion: Mutation of p53 gene may affect the overexpression of mdr 1 gene activity Monitoring p53 and P gp gene products at the early stage of breast cancer is of importance