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类胰蛋白酶与疾病 被引量：7

Trptase and its relationship with disease
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摘要 Thyptase,a predominant serine protease in mast cells,is released by mast cell degranulation in an enzymatically active form.Recent research suggests that ttyptase plays important roles in mast cell mediated anaphylaxis,angiogenesis,initiation and promotion of neoplasm.This paper reviews tryptase’s struture,molecular biology,biochemistry,processing,activation and its relationship with diseases. Thyptase,a predominant serine protease in mast cells,is released by mast cell degranulation in an enzymatically active form.Recent research suggests that ttyptase plays important roles in mast cell mediated anaphylaxis,angiogenesis,initiation and promotion of neoplasm.This paper reviews tryptase's struture,molecular biology,biochemistry,processing,activation and its relationship with diseases.
作者 陆超 殷莲华 金惠铭
机构地区 复旦大学上海医学院生理与病理生理学系教研室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2002年第6期718-721,共4页 Chinese Journal of Pathophysiology
关键词 分子生物学 生物活性 过敏性疾病 肿瘤 类胰蛋白酶 肥大细胞增多症 疾病 Ttyptase Mast cells Disease
分类号 R363 [医药卫生—病理学] R730.23 [医药卫生—肿瘤]
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参考文献18

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  • 3[3]Pereira PJ,Bergner A,Macedo Ribeiro S,et al.Human βtryptase is a ring - like tetramer with active sites facing a central pore[J].Nature,1998,392(6673): 306- 311.
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  • 8[8]Jolnson PR,Ammit A J,Carlin SM,et al.Mast cell tryptase potentiates histamine - induced contraction in human sensitized bronchus[J].Eur Respir J,1997,10(1): 38- 43.
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同被引文献109

引证文献7

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中国病理生理杂志
2002年 第6期

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