辛伐他汀治疗老年高脂血症125例效果观察

Curative and untoward effects of simvastalin on hyperlipemia in elderly patients

选择总胆固醇 (TC)≥ 6.5 mmol/L、伴有或不伴有甘油三酯 (TG)≥ 1.7mmol/L和高密度脂蛋白(HDL-c)≤ 1.0 4mmol/L患者 2 5 6例 ,其中老年组 12 5例 ,中青年组 (对照组 ) 13 1例 ,给予辛伐他汀 10 mg/d口服 ,于用药 4周、用药 8周分别测定血脂、脂蛋白、载脂蛋白、血常规、肝肾功能等 ,并仔细询问服药后的不良反应。结果 :辛伐他汀降低总胆固醇 (TC)和载脂蛋白 B1 0 0 (apo B1 0 0 )水平 ,升高 apo A /apo B1 0 0 比值 ,老年组明显小于中青年组。用药后的副作用老年组多于中青年组。认为 :辛伐他汀对老年高脂血症患者的疗效不如中青年患者 。

To study curative effect and untoward effect of simvastatin on hyperlipemia in elderly patients,256 patients with hypercholesterolemia were divided into the two groups,elderly patients group(125 cases)and young patients group(131 cases).All patients received simvastatin(10mg/d) treatment.Total cholesterol, HDL cholesterol, triglycerides, apolipoprotein A,apolipoprotein B,blood routine,routine uronoscopy,liver and renal function were measured in all patients at 4th week and 8th week after medicate.Untoward effect were observed carefully after medicate.The results showed that the effect of simvastatin lowering total cholesterol and apolipoprotein B levels was smaller in elderly patients with hyperlipemia than that in young patients.The effect of simvastatin increasing the ratio of apolipoprotein A to apolipoprotein B was also smaller in elderly patients with hyperlipemia than that in young patients. Untoward effect of simvastatin was higher in elderly patients with hyperlipemia than that in young patients.These suggested that curative effect of simvastatin was smaller in elderly patients with hyperlipemia than that in young patients. Untoward effect of simvastatin was higher in elderly patients with hyperlipemia than that in young patients.