口服化学药物疗法对胰头癌根治术患者的疗效分析

The effect of oral chemotherapy in patients of adenocarcinoma of the head of the pancreas after radical resection

目的 探讨口服化疗对胰头癌根治手术后患者的疗效。方法 4 8例患者在胰头癌根治性切除术后分为化疗组 2 4例 ,口服化疗药物 5′ 脱氧 5 氟脲嘧啶 (5′ DFUR ,商品名 :氟铁龙 )加甲酰四氢叶酸钙连续 6个月 ,对照组 2 4例未行化疗。结果 全部 4 8例共有 12例死亡 ,化疗组有 5例死亡 ,包括肝转移 2例、局部复发 2例 ,对照组 7例患者均由于肝转移死亡。 2组肝转移的发生率之间相比差异有显著意义 (P <0 0 5 )。化疗组 1年、2年、3年生存率分别为 84 %、5 7%、4 9% ;对照组的 1年、2年生存率分别为 80 %、4 0 %。

Objective To study the effect of oral chemotherapy on patients of pancreatic carcinoma undergoing Whipple′s procedure. Methods48 cases undergoing radical pancreaticoduodenectomy with regional lymphadenectomy were divided into two groups. 24 cases received oral chemotherapy consisted of 5′ DFUR and calcium folinate for a course of 6 months. ResultsThe clinicopathological features were similar between the two groups. During the period of follow up,5 cases in chemotherapy group died including motality caused by liver metastasis in 2 cases whereas 7 cases died of liver metastasis in the control group( P <0 05). The 1 , 2 , and 3 year accumulated survival rate was 84%, 57% and 49% in chemo group, while the 1 , and 2 year survival rate was 80%, 40% in control group, respectively. ConclusionsOral chemotherapy decreasing liver metastasis has a favourable effect on the prognosis of patients with carcinoma of the head of the pancreas undergoing radical pancreaticoduodenectomy .