高渗复合液治疗失血性休克的机制研究

The dehydration effect of hypertonic saline solution (HSS) in the treatment of hemorrhagic shock

目的 研究高渗复合液的脱水作用治疗失血性休克的机制。方法 利用大鼠Wigger′s失血性休克模型 ,通过对比不同复苏液对大鼠下肢腓肠肌水含量的影响来评价高渗复合液的作用效果。结果 在出血性休克并复苏后 ,高渗复合液组的组织水含量 (73 0 %± 1 5 % )较平衡液组(74 8%± 2 0 % )及对照组 (75 4 %± 1 6 % )少 ,差异有显著意义 (P <0 0 5 )。结论 高渗复合液无论在休克状态与水肿状态均可以将细胞和间隙内的水分抽取至血管内 ,从而扩大血容量。

ObjectiveTo evaluate the dehydration effect of HSS in the treatment of hemorrhagic shock and to explore the mechanism.MethodsWigger′s hemorrhagic shock model was established in three groups of rats (10 rats in each group), shock was treated by no infusion in control. Lactated Ringer′s solution started one hour later in a dosage of 8 ml/kg given within 5 mins in Ringer′s group and in HSS group, Ringer′s solution was substituted by HSS.Results The water content of gastrocnemius in normal, nothing to infuses. Ringer′s and HSS group was respectively 75 3%±1 4%, 75 4%±1 6%, 74 8%±2 0%, and 73%±1 5%, a significant difference was observed between the last 3 groups (all P <0 05). ConclusionsOur result shows that the infusion of HSS extracts water from intracellular and interstitial space and into plasma expanding the plasma volume.