p53基因在大肠癌中的表达及预后意义

Expression of p53 gene associated with prognosis in colorectal cancer

目的 探讨 p5 3基因在大肠癌组织中的表达及与预后的相关性。方法 应用免疫组织化学 SP法检测了 12 0例大肠癌组织中 p5 3蛋白的表达。结果 p5 3蛋白在本组大肠癌组织中阳性表达率为 6 2 .5 % (75 /12 0 )。 p5 3蛋白的表达与大肠癌患者的性别、年龄、肿瘤大小、大体分型、肿瘤部位、组织学分级、淋巴结转移、浸润深度、Dukes′分期均无关 (P>0 .0 5 )。p5 3蛋白的表达与大肠癌预后有关 ,p5 3蛋白阳性表达组术后生存率明显低于阴性表达组 (P<0 .0 0 0 1)。结论 p5 3基因可能是影响大肠癌患者生存的一个重要预后指标。

Objective To investigate the expression of p53 protein and its relationship to prognosis of colorectal carcinoma(CRC).Method Streptavidin peroxidase immunohistochemical technique was adopted to detect the expression of p53 in 120 cases of CRC.Results The data showed that positive expression rate of p53 was 62.5%(75/120).The expression of p53 protein did not correlate with patient′s sex,age,size of tumor,macroscopic configuration,tumor location,histological grade,lymph nodes metastasis,depth of invasion and Duke′s classification (P>0 05).The cases with p53 gene positive expression had much lower survival rate than those with negative expression (P<0 000 1).Conclusion p53 is an important prognostic factor in the survival of patients with CRC probably.