摘要
探讨了乳腺癌组织的多药耐药现象的主要机制及P-糖蛋白(P-gp)、胎盘型谷胱甘肽硫转移酶(GST-π)与99Tcm-MIBI显像的关系。尽管文献报道的实验结果不尽相同,但作为一种功能显像技术,99Tcm-MIBISPECT显像能够用来研究乳腺癌细胞P-gp的表达,可以在体外无创性检测乳腺癌多药耐药,为指导乳腺癌的治疗提供参考。
This article discus se d the main mechanism of multidrug resistance of breast cancer tissues,and the c orrela-tion between technetium-99m sestamibi ( 99 Tc m-MIBI )breast imaging results,with the expression of drug resistance pro-teins P-glycoprotein and glutathione-S-transfease-餴n human breast cancer .Though not all the results reported before matched each other,as a kind of a noninvasive simple functional test imaging technology in vitro,SPECT can be use d to diagnose P-glycoprotein expression in breast cancer,and can be used to pr edict chemotherapy response.
出处
《国外医学（放射医学核医学分册）》
2002年第2期67-71,共5页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
