摘要
BNCT(硼中子俘获治疗)基于这样一种思想:10B的载体化合物会优先选择癌细胞作为靶而后与热中子反应,进而产生高能、短射程裂变产物α粒子和Li粒子。它是一种双重的靶向治疗方法。BNCT的治疗效果依赖于两个主要因素:源于10B(n,α)7Li核反应的高LET(传能线密度)粒子的生物效应和在靶细胞及其特异区域内的硼沉积。本文总结和探讨了BNCT的发展概况、辐射场的特点以及吸收剂量的计算方法。
Boron ne ut ron capture therapy(BNCT)is based on the nuclear reaction that occurs when bor on-10is irradi-ated with low-energy thermal neutrons to yield alpha particl es and recoiling lithium-7nuclei which have high energy and short-range.BNCT is a binary approach:a boron-labeled compound is administered that delivered high concen tration of 10 B of the target tumor relative to the surrounding tissues.The therapeutic e fficiency of BNCT is depended upon RBE and LET of the reaction and particles and the boron selectivity to cancerous cells.The development of BNCT,character-istic of radiation fields and calculations of energy deposition are described in this paper.
出处
《国外医学（放射医学核医学分册）》
2002年第2期87-89,共3页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
