开肺陷胸汤对大鼠胰源性肺损伤的防治效应

Preventive and Therapeutic Effects of Kaifei-Xianxiong Decoction on Pancreatogenic Lung Injury in Rats

目的 :在制备大鼠胰源性肺损伤动物模型基础上给予中药治疗 ,动态观察血氧分压及二氧化碳分压变化 ,并对肺脏进行病理学分析。 方法 :实验分为模型组及中药治疗组 ,72h后观察肺脏病理变化及不同时间血气分析。 结果 :治疗组肺脏病理改变明显减轻 (P <0 0 5 ) ;治疗组 72h血氧分压明显高于模型组 (P <0 0 1) ,血二氧化碳分压明显低于模型组 (P <0 0 1)。 结论 :在胰源性肺损伤发病过程中 ,血氧分压及二氧化碳分压的变化直接反应出肺损伤病理改变的严重程度 ,治疗组随着氧分压升高 ,二氧化碳分压降低 ,标志着肺脏病理改变明显减轻。

Objective:To observe the pathologic changes and blood gas changes of pancreatogenic lung injury in rat and the effects of herbal decoction Methods:Dynamic change of PaO 2 and PaCO 2 and the pathologic changes of the lung in pancreatogenic lung injury in rat models were observed.Thirty rats were divided into two groups,the control and Chinese herbal treatment(Kaifei-Xianxiong Decoction)groups.Before and after injury and 72 hours after injury,blood samples were taken for blood gas analysis and pathologic examination of the lung was observed.Results:There were significant differences between the control and treatment groups,the PaO 2 in the treatment group was higher than the control( P <0.005).Lung tissues injuries were milder in the treatment group than in control group.Conclusion:Chinese herbs(Kaifei-Xianxiong decoction)play a potent effective role in the treatment of pancreatogenic acute lung injury.