前列腺痛患者情绪障碍的分析及治疗

Mood disorders in prostatodynia and its treatment

目的 :探讨情绪障碍与前列腺痛的关系及抗抑郁药的治疗效果。方法 :对 5 6例前列腺痛患者进行抑郁自评量表 (SDS)、焦虑自评量表 (SAS)、美国国立卫生研究所的慢性前列腺炎症状积分指数 (NIH -CPSI)评分 ;用抗抑郁药盐酸氟西汀 (商品名 :百忧解 )治疗 3 2例有抑郁障碍的前列腺痛患者 ,疗程为 8周 ,治疗后再行量表评分。结果 :SAS及SDS的检测结果与我国常模比较明显增高 (P <0 .0 1 ) ;3 2例有抑郁障碍的患者治疗后NIH CPSI总分、SDS标准分、SAS标准分显著下降 ,治疗后 8周的NIH CPSI总分与SDS标准分、SAS标准分呈正相关 (r =0 .80 7,P <0 .0 1 ;r =0 .81 1 ,P <0 .0 1 ) ,与SDS标准分、SAS标准分下降率呈负相关 (r =-0 .84 2 ,P <0 .0 1 ;r =- 0 .6 99,P <0 .0 1 )。结论 :前列腺痛与情绪障碍相关 ;前列腺痛患者普遍存在抑郁和焦虑情绪 ,用抗抑郁药治疗能显著改善精神和躯体两方面症状。

Purpose:To investigate the role of mood disorders in prostatodynia and the effects of antidepressive agents on prostatodynia.Methods:To analyze the mood disorders of 56 patients with prostatodynia using self rating depressing scale(SDS), self rating anxiety scale(SAS) and the National Institutes of Health chronic prostatitis symptom index (NIH CPSI). In 32 prostatodynia patients with depressive disorder, antidepressive agent (fluoxetine) had been used for 8 weeks. Psychological analysis was done after treatment.Results:The scores of SDS, SAS in prostatodynia were significantly higher than the normal(P< 0.01 ). Of 32 prostatodynia patients with depressive disorder, the scores of NIH CPSI, SDS, SAS were significantly decreased after treatment (P< 0.01 ).The scores of NIH CPSI after 8 weeks treatment showed a positive correlation with those of SDS, SAS(r= 0.807 ,P< 0.01 ;r= 0.811 ,P< 0.01 ) and showed an inverse correlation with the score decrease rates of SDS, SAS(r= -0.842 ,P< 0.01 ;r= -0.699 ,P< 0.01 ). Conclusions:Mood disorders play a role in prostatodynia. Depression or anxiety commonly occurred and antidepressive agents are effective for improving both somatic and psychological symptoms.