TGF-β_1及α-SMA在积水肾盂组织中的表达及其相关性研究

Expression and significance of TGFβ 1 and αSMA in human renal pelvis of hydronephrosis

目的 :检测转化生长因子 β1 (TGF β1 )和α 平滑肌肌动蛋白 (α SMA)在肾积水肾盂肌层的表达 ,以探讨TGF β1 对积水肾脏的保护作用。方法 :应用免疫组织化学方法对 3 0例积水肾盂和 5例正常肾盂标本进行染色观察。结果 :积水肾盂标本TGF β1 和α SMA的表达较正常肾盂标本均增高 (P <0 .0 1 ) ,且二者存在显著正相关关系 (r =0 .71 ,P <0 .0 5 )。结论 :TGF β1 通过促进肾盂肌层肥厚在肾积水的病理生理过程中发挥保护作用。

Purpose:To detect the expression of TGFβ 1 and αSMA in renal pelvis of hydronephrosis and to investigate the protective role of TGFβ 1 in the pathophysiologic course of hydronephrosis.Methods:The expression of TGFβ 1 and αSMA protein was determined in 30 renal pelvis specimens with hydronephrosis and 5 normal control specimens by immunohistochemistry. Results:The expression of TGFβ 1 and αSMA are obviously increased in muscle layer of hydronephrotic renal pelvis compared to the normal renal pelvis specimens, P< 0.01 , and TGFβ 1 statistically correlates positively to αSMA, r= 0.71 ,P< 0.05 . Conclusions:TGFβ 1 may be one of the protective factors in the pathophysiologic course of hydronephrosis by inducing muscle hypertrophy of renal pelvis.