硬肝复康对小鼠免疫性肝损伤的作用

Effects of Ying-gan-fu-kang on Mice With Immunological Liver Damage

目的 研究硬肝复康对实验性慢性活动性肝炎的防治作用。方法 给小白鼠静脉注射卡介苗 (BCG)和细菌脂多糖 (LPS)以造成免疫性肝损伤 ,检测其血清酶、蛋白、过氧化脂质等指标。结果 硬肝复康防治组血清谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、过氧化脂质 (LPO)均低于对照组 (P<0 0 1) ;碱性灰磷酸酶 (ALP)和脾脏指数也呈降低趋势 ;肝脏指数及血清总蛋白量 (TP)则无明显改变。

Objective:To study the effects of Ying gan fu kang (GFK) on experimental chronic active hepatitis in mice. Methods: The mice were injected (iv) with BCG and LPS to induce immunological liver injury and their serum enzymes, proteins and lipid peroxides (LPO) were assayed. Results: The mice serum ALT(36.3 u/L±13.0 u/L), AST(164.4 u/L±17.2u/L), LPO(10.79 u/L±2.18nmol/L) of the GFK group were significantly decreased than that of the control group (83.2±52.6, 235.5±73.4 and 14.22±2.45) (P<0.01). The serum ALP and spleen index of GFK group were a little lower than control group; the serum total protein and Alb and liver index had no evident change. Conclusion: GFK is of well preventive and curative effects on experimental chronic active hepatitis.