生物活性聚乙烯醇羟基磷灰石复合水凝胶的结构与性能

Structure and Properties of Bioactive Compound Hydrogels Made from Poly(vinyl alcohol)

本工作研究了聚乙烯醇和羟基磷灰石复合型生物活性水凝胶 ,探讨了工艺条件和配方对其拉伸强度 ,压缩强度 ,粘弹性、润滑性等生物力学性能的影响 ,观察和比较了复合水凝胶的微观形貌。研究表明聚乙烯醇和羟基磷灰石可形成接近纳米级的均匀分散结构 ,良好相容 ,使复合凝胶的力学强度和润滑性能提高 。

A kind of compound hydrogels consisted of polyvinyl alcohol(PVA) and hydroxyl apatite(HA) were designed as bioactive artificial cartilage.The components and processing conditions were studied for preparation of optimum hydrogels with good lubricating feature and high bioactivity.The properties,such as stretch strength,compress strength,friction,compress stress relaxation of various compound hydrogels were compared.The micro\|morphology of PVA\|hydrogels and PVA/HA\|hydrogels were investigated by a way of SEM.It was found that the addition of HA could improve the lubricating feature and mechanical strength of hydrogels,The SEM observation indicated that HA had a significant effect on the molecular arrangement of PVA which lead to the changes of their surface morphology.