摘要
目的 制作大鼠溃疡性结肠炎 (UC)模型 ,研究结肠电异常。方法 以二硝基氯苯法制作溃疡性结肠炎模型 ,埋藏电极记录结肠电。结果 造模大鼠结肠形成典型的溃疡 ,并发现其结肠电活动明显异常 ,具体表现为基本电节律 (BER)减慢及收缩性复合肌电 (CEC)的幅值显著降低 。
objective To establish a rat ulcerative colitis(UC) model and observe the abnormality of its electrical activity of colon.Methods The rat-models of ulcerative colitis were induced by 2,4-dinitrochlorobenzene(DNCB),an electrode was buried in rats' colon and their colonic electricity was recorded.Conclusion It was found that colon of rat-models developed typical ulceration and colonic electricity was abnormal,the basic electric rhythm(BER) of colon was slowed;extent of contractile electrical complex(CEC) was decreased and the percentage of BER and CEC loaded with peak electricity were markedly lowered.
出处
《实验动物科学与管理》
2002年第2期5-7,共3页
Laboratory Animal Science & Administration
基金
广东省自然科学基金资助项目 (No.96 0 5 45 )
