大手术后机械通气的危重病人异丙酚的临床应用

Clinical application of propofol in critical patients with mechanicalventilation after major operation

目的探讨危重病人行机械通气时异丙酚的临床应用价值。方法22例大手术后需要机械通气的危重病人随机分为两组 ,每组11例 ,A组为对照组 ,B组为异丙酚组 ,持续静脉微泵注入异丙酚。观察两组病人的临床表现、血压、心率及血浆肾上腺素(E)、去甲肾上腺素(NE)浓度变化。结果异丙酚组病人均处于浅睡眠状态 ,脱机时对照组病人血压、心率、血浆E、NE浓度均明显升高 ,两组间比较有显著性差异(P<0.05)。结论异丙酚能使机械通气的危重病人处于浅睡眠状态 ,能抑制病人体内E、NE的释放 。

Aim To evaluate the clinical application of propofol in critical patients with mechanical ventilation.Methods 22 patients with mechanical ventilation after major operation were randomly divided into control group and propofol group patient in the propofol group were continually transfused with propofol by micro pump.Clinical manifestations, blood pressure, heart rate and the concentration of epinephrine (E) and norepinephrine (NE) in patients of both groups were observed.Results The patients in propofol group were all in sleeping state, while those in the control group had evidently higher blood pressure, heart rate and the concentration of epinephrine and norepinephrine after wearing of ventilator.There was a significant difference between the two groups (P<0.05).Conclusion Propofol can make the critical patients quiet and in a sleeping state,inhilit the release of epinephrine and norepinephrine, which rescdt in hemodynamic stability.