造血干细胞基因治疗研究进展
被引量：2
Advances of Study on Gene Therapy Based on Haemotopoietic Stem Cells
摘要
近几年来,造血干细胞基因治疗在逆转录病毒载体,动物模型和临床试验等方面取得了明显进展。最近,国外采用该方法临床治疗两名SCID-X1患儿获得成功,这是基因治疗单基因疾病领域的一个重大里程碑。
出处
《生命的化学》
CAS
CSCD
2002年第3期253-255,共3页
Chemistry of Life
参考文献17
-
1Thomson JA et al. Science, 1998,282:1145-1147
-
2Shamblott MJ et al. Proc Natl Acad Sci USA, 1998,95: 13726-13731
-
3Jackson KA et al. Proc Natl Acad Sci USA, 1999, 96(25): 14482-14486
-
4Weissman IL. Cell, 2000, 100:157
-
5Weissman IL. Science, 2000, 287: 1442-1446
-
6Kiem HP et al. Blood, 1997, 90(11):4638-4645
-
7Kiem HP et al. Gene Ther, 1999, 6(6) :966-972
-
8KiemHPetal. Blood, 1998, 92(6):1878-1886
-
9Miyoshi H et al. science, 1999,283:682-686
-
10Huhn RD et al. Hum Gene Ther, 1999,10(11):1783-1790
同被引文献18
-
1Takebe N, Zhao SC, Ural AU, Johnson MR, Banerjee D, Diasio RB, Bertino JR. Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34+-enriched peripheral blood progenitor cells. Cancer Gene Ther 2001;8:966-973.
-
2Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 1992;257:99-103.
-
3Capiaux GM, Budak-Alpdogan T, Takebe N, Mayer-Kuckuk P, Banerjee D, Maley F, Bertino JR. Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil. Hum Gene Ther 2003;14:435-446.
-
4Eliopoulos N, Al-Khaldi A, Beausejour CM, Momparler RL, Momparler LF, Galipeau J. Human cytidine deaminase as an ex vivo drug selectable marker in gene-modified primary bone marrow stromal cells. Gene Ther 2002;9:452-462.
-
5Beausejour CM, Eliopoulos N, Momparler L, Le NL, Momparler RL. Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene. Cancer Gene Ther 2001;8:669-676.
-
6Asai S, Miyachi H, Kobayashi H, Takemura Y, Ando Y. Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin. Cancer Sci 2003;94:210-214.
-
7Banerjee D, Mayer-Kuckuk P, Capiaux G, Budak-Alpdogan T, Gorlick R, Bertino JR. Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. Biochim Biophys Acta 2002;1587:164-173.
-
8Sweeney CL, Frandsen JL, Verfaillie CM, McIvor RS. Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase. Cancer Res 2003;63:1304-1310.
-
9姜祥祺,高龙关,荣德载,黄良社.钠Y型分子筛低压吸附特性的实验研究[J]真空科学与技术,1983(01).
-
10王红美,沈柏均.CD34^-造血干细胞的研究进展[J].国外医学（输血及血液学分册）,2000,23(5):342-345. 被引量：1
引证文献2
-
1郑伟国,郭英.造血干细胞及其临床应用[J].口岸卫生控制,2004,9(4):42-46.
-
2路平,金锋,陈波,姚凡,王舒宝,陈峻青,徐惠绵,赵实诚.DHFR-CD双耐药基因增强转基因小鼠对大剂量化疗毒性的抵御能力[J].世界华人消化杂志,2005,13(4):464-467.
-
1惠文波,鲁亚平.帕金森病细胞移植治疗研究进展[J].生物学教学,2014,39(6):4-7.
-
2董文吉,祖振响,刘德培,梁植权.病毒载体与造血干细胞基因治疗[J].Acta Genetica Sinica,2003,30(4):383-388. 被引量：5
-
3周立权,周建光,洪宝发.哺乳动物RNA干涉及治疗研究进展[J].军医进修学院学报,2005,26(1):76-77.
-
4李安琪,翟静.腺相关病毒载体介导的肿瘤基因治疗研究进展[J].世界临床药物,2010,31(11):687-690. 被引量：7
-
5朝日.划时代的基因治疗免疫不全症[J].知识就是力量,2001(2):14-15.
-
6吴旻.抑癌基因研究展望[J].中国优生与遗传杂志,1990,0(2):74-74.
-
7我国独创疾病基因完整体系[J].海内与海外,2001(2):45-46.
-
8廖夏林.基因治疗在临床上的应用[J].抚州师专学报,2000,19(4):48-49. 被引量：3
-
9王婷婷.浅析电针治疗阿尔茨海默病的神经生物学的研究[J].科技视界,2016(19):119-119.
-
10Jin-min GUO Ai-jun LIU Ding-feng SU.Genetics of stroke[J].Acta Pharmacologica Sinica,2010,31(9):1055-1064. 被引量：3
