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老年冠心病患者血浆血小板活化因子和血清可溶性细胞间粘附分子-1测定及其临床意义 被引量:7

Detection and clinical significance of plasma PAF and serum sICAM-1 in elderly patients with coronary heart disease
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摘要 目的 研究老年冠心病患者血浆血小板活化因子 (PAF)和血清可溶性细胞间粘附分子 1(sICAM 1)水平的变化及其相互关系。方法 采用ELISA法和生物学方法分别测定 6 5例老年冠心病 (CHD组 )患者 [2 5例稳定型心绞痛 (SA组 ) ,2 1例不稳定型心绞痛 (UA组 ) ,19例急性心肌梗塞 (AMI组 ) ]和 32名健康人 (对照组 )血浆PAF和血清sICAM 1水平。结果  ( 1)CHD组PAF和sICAM 1水平与对照组比较均显著升高 (P <0 .0 1,P <0 .0 1) ;( 2 )SA组PAF和sICAM 1水平与对照组比较 ,差异无显著性 (P >0 .0 5 ) ;( 3)UA组和AMI组PAF和sICAM 1水平比对照组明显升高 (P <0 .0 0 1,P <0 .0 5 ) ;( 4 )UA组与SA组比较 ,血浆PAF水平明显升高 (P <0 .0 1) ,血清sICAM 1水平升高无明显差异 (P >0 .0 5 ) ;( 5 )AMI组与SA组比较 ,血浆PAF及血清sICAM 1水平的升高均有明显差异 (P <0 .0 0 1)。结论 PAF及sICAM 1参与老年冠心病的发生、发展过程 ,其测定可作为老年冠心病的临床诊断、治疗及预后观察的一个临床指标。 Objective To observe the levels of plasma platelet activating factor(PAF) and serum soluble intercellular adhesion molecule 1(sICAM 1) and their relationship in elderly patients with coronary heart disease(CHD). Methods The levels of plasma PAF and serum sICAM 1 in 65 patients with CHD, [indluding 25 stable anginas(SA),21 unstable anginas(UA),19 acute myocardial infarctions (AMI) and 32 healthy subjects(control group) were detected by ELISA or bio assay. [WT5'HZ]Results The levels of plasma PAF and serum sICAM 1 in patients with CHD were significantly higher than those in control group ( P <0.001; P <0.01); The levels of plasma PAF and serum sICAM 1 in patients with SA were not significantly different as compared with in control group ( P >0.05),the level of plasma PAF and serum sICAM 1 in patients with UA and AMI were significantly higher than those in control group( P <0.001; P <0.05);the level of plasma PAF in patients with UA was significantly higher than that in patients with SA( P <0.01), the level of serum sICAM 1 in patients with UA was not significantly higher than those in patients with SA( P >0.05), the levels of plasma PAF and serum sICAM 1 in patients with AMI were significantly higher than those in patients with SA( P <0.001).Conclusion The PAF and sICAM 1 participate in the occurrence and development of elderly patients with CHD, the detection of plasma PAF and serum sICAM 1 can be served as a clinical index of the diagnosis, therapy and prognosis of the elderly patients with CHD.
出处 《临床内科杂志》 CAS 北大核心 2002年第3期205-207,共3页 Journal of Clinical Internal Medicine
基金 江苏省教育厅自然科学基金资助项目 (99KJD32 0 0 0 7)
关键词 老年人 冠心病 血浆 血小板活化因子 血清 可溶性细胞间粘附分子-1 测定 临床意义 Coronary heart disease Platelet activating factor Intercellular adhesion molecule
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  • 8许文荣,顾可梁,曹红翠,孙晓春,曹长春.血浆溶血血小板活化因子测定及在儿童哮喘中应用[J].临床检验杂志,1997,15(5):265-267. 被引量:14

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