摘要
用单相动作电位记录技术 ,在应用β受体阻滞剂前、后刺激交感神经过程中 ,同步记录 18只开胸犬基础及急性缺血条件下左心室游离壁心外膜、中层心肌和心内膜心肌细胞的单相动作电位。结果表明交感神经刺激使跨室壁复极离散度 (TDR)减小。急性缺血可使 TDR增加 ,交感神经刺激使 TDR进一步由 (5 4± 7) ms增加到 (83± 13) m s (P<0 .0 1) ,而且可以在中层心肌诱发出早期后除极 (EAD)。
By using the monophasic action potential (MAP) recording technique, MAP of the epicardium (Epi), midmyocardium (Mid) and endocardium (Endo) was recorded simultaneously at the left ventricular free wall under normal condition and acute ischemic condition in 18 open chest dogs before and after β receptor blocker application during sympathetic nerve stimulation. The results showed that the sympathetic nerve stimulation could shorten the transmural dispersion of repolarization (TDR), the acute myocardial ischemia could increase the TDR, the sympathetic nerve stimulation could further increase the TDR (from 54±7 ms to 83±13 ms), and could induce the EAD on the Mid. The β receptor blocker can fully block the effects of the sympathetic nerve stimulation.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2002年第3期269-272,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
关键词
Β受体阻滞剂
在体犬
研究
急性心肌缺血
单相动作电位
跨室壁复极离散度
receptor blocker
sympathetic nerve
acute myocardial ischemia
monophasic action potential
transmural dispersion of repolarization
