肺炎衣原体感染与动脉粥样硬化的关系

Assessment of association between chlamydia pneumoniae infection and atherosclerosis

目的 研究肺炎衣原体 (Cpn)感染与动脉粥样硬化(AS)关系和Cpn特异性抗体检测的临床意义。方法 采用间接免疫荧光试验 ,对 6 7例冠心病 (CHD)、32例心肌梗死(MI)患者和 40名正常人 (对照组 )的血清进行了Cpn特异性IgG、IgA、IgM抗体的检测。 结果 显示CpnIgG抗体的阳性率患者组与对照组之间差异无显著性 (P >0 0 5 ) ,CpnIgA抗体的阳性率患者组高于对照组 (P <0 0 1) ;CpnIgG、IgA抗体滴度和几何平均滴度患者组高于对照组 (P <0 0 1)。结论 Cpn抗体滴度有助于疾病的诊断 ;持续高滴度的CpnIgG、IgA抗体可作为Cpn慢性感染的重要指标 ;慢性Cpn感染是AS发生、发展的重要危险因素。

Objective To find out the association between Chlamydia pneumoniae infection and atherosclerosis and investigate the clinical significance of antibodies against Chlamydia pneumoniae. Methods Chlamydia pneumoniae-specific serum IgG?IgA?IgM antibodies were measured by indirect immunofluorescence test in 67 patients with coronary heart disease, 32 patients with myocardial infarction and 40 normal persons. Results Significance difference of the positive rate of specific IgG antibodies was not found between observation group and control group (P>0.05). Significant difference of the positive rate of specific IgA antibodies was found between observation group and control group (P<0.01). Significance difference of the positive rate of Cpn-specific IgG,IgA antibody titers and the geometric mean titers(GMT) was also found between observation group and control group (P<0.01). Conclusion Cpn-specific IgG, IgA antibody titers will help diagnose the diseases. Persistent higher titer Cpn-specific IgG,IgA antibodies may be considered as important markers of chronic Chlamydia pneumoniae infection. Chronic Cpn infection may be a significant risk factor for the development of atherosclerosis.