胃舒康混悬液对实验性胃溃疡的药效学研究

Study on Pharmacodynamics of Weishukang to Experimental Gastric Ulcer

目的 复制动物实验性胃溃疡模型,研究胃舒康的药效学并探讨其作用机制。方法 ①将小鼠随机分为对照组和实验组,实验组以胃舒康混悬液(7.5g/kg、3.75g/kg)灌胃,每天1次,共7天。末次灌胃后腹腔注射冰醋酸每只0.2ml,记录各组小鼠扭体反应的潜伏期和扭体反应次数。②将小鼠分为对照组和实验组。实验组以胃舒康混悬液(7.5g/kg、3.75g/kg)灌胃,每天1次,连续7天。末次灌胃后腹腔注射利血平(10ml/kg)复制胃溃疡模型,观察胃舒康混悬液对胃溃疡的保护作用。结果 胃舒康混悬液能延长小鼠扭体反应的潜伏期和减少扭体反应的次数,与空白对照组比较差异显著,P<0.05;对利血平型胃溃疡可显著降低溃疡指数,与对照组比较具有显著性差异,P<0.05。结论 胃舒康混悬液对实验性小鼠具有镇痛作用和胃粘膜保护作用。

Objective To replicate animal's pathological patterns, study the pharmacodynamics of Weishukang and! detect its mechanism.Methods ①The mice were randomly divided into four groups, which were the control group,Weishukang groups, and aspirin group.Normal saline(NS),suspended Weishukang(7.5 g/kg,3.75 g/ kg), aspirin were respectively taken with ig,once a day, consecutive seven days. At last day, ice acetic acid were taken with ip after experimental drugs were taken with ig.Then the latent period and times of wrenching body reaction were recorded.②The mice were randomly divided into four groups, which were control group, Weishukang groups, and cimetidime group.Normal saline(NS),suspended Weishukang(7.5 g/ kg,3.75 g/kg),cimetidime were respectively taken with ip,once a day,consecutive seven days. At last day,reserpine were taken with ip after experimental drugs were taken with ig, in order to replicate gastric ulcer mold of small mice, and to observe the protective effects of Weishukang on gastric mucosa. Result Wrenching can prolong the latent period of mice wrenching body reaction and reduce the times of wrenching body reaction. Compared with the non-drug group the difference is significant( P < 0. 05) .Gastric ulcer patterns with reserprine can obviously reduce the index of ulcer, and compared with the group of pathological patterns it has a remarkable difference ( P < 0.05). Conclusion Weishukang has the analgesia and protective effects on gastric mucosa in the experiment on mice.