实施心肺复苏期间患者血栓素A_2和前列环素动态变化的临床研究

Study of the dynamic changes of thromboxane A_2 and prostacyclin in patients during cardiopulmonary resuscitation.

目的探讨血管活性物质血栓素 A2 (TXA2 )和前列环素 (PGI2 )在心肺复苏过程中的意义。方法 2 0例心脏骤停行心肺复苏术患者 ,根据复苏后有无自主循环分组 :缺血组 (8例 )和再灌流组 (12例 )。缺血组于复苏前 ,复苏开始即刻、15、3 0分钟时 ;再灌流组于复苏前 ,复苏后即刻、15、3 0分钟时 ,分别测定血浆中血栓素 B2 (TXB2 )和 6-酮 -前列腺素 F1α的浓度 ;比较两组患者上述指标的动态变化 ,并设正常对照组。结果再灌流组 :TXB2 浓度在恢复自主循环即刻明显增高 ,随后逐渐下降 ,但与缺血组无显著差异 ;6-酮 -前列腺素 F1α浓度在恢复自主循环后明显增高 ,且明显高于缺血组。结论 TXA2 、PGI2 参与了心肺复苏期间的再灌注 ,动态监测血中 TXA2 、PGI2

Objective To explore the significance of thromboxane A 2(TXA 2) and prostacyclin(PGI 2) in cardiopulmonary resuscitation.Methods 20 cases with sudden cardiac arrest receiving cardiopulmonary(CPR) were divided into two groups:ischemia group(n=8) and reperfusion group(n=12).TXB 2 level and 6 Keto PGF 1α were determined before CPR and at 0,15,30 minutes after CPR in two groups.Normal subjects were taken as controls.Results As for reperfusion group,TXB 2 level was obviously increased immediately after CPR and then dropped,but there was no significant difference with ischemia group; 6 Keto PGF 1α level was obviously increased and was clearly higher than that in ischemia group after CPR.Conclusion TXA 2 and PGI 2 are involved in reperfusion during CPR.Dynamic monitoring of TXA 2 and PGI 2 is valuable to the prognosis of the patients with CPR.