老年男性各年龄组骨密度与骨代谢生化指标的关系

The relationship of bone mineral density and bone metabolic markers in the different age of old men

目的 测定老年男性不同年龄组骨密度及血、尿中与骨吸收和骨形成有关的生化指标 ,观察其与年龄的关系 ,探讨以上生化指标对早期诊断原发性骨质疏松的临床意义。方法 采用双能量 X线骨密度测定仪测定前臂骨密度 ;采用全自动生化分析法测定血清碱性磷酸酶(ALP)、尿钙 (Ca)、肌酐 (Cr) ;采用放免法测定骨钙素 (BGP)、抗酒石酸酸性磷酸酶 (TRAP)、尿羟脯氨酸 (HOP)。将年龄 60～ 95岁的老年男性 97例分为 60～ 69岁、 70～ 79岁和 80岁以上三组并与 60岁以下男性进行比较。再将其分为骨质疏松组与非骨质疏松组 ,比较其测定值。结果 老年男性骨密度及骨形成与骨吸收指标呈现随着年龄增长而降低的趋势。其中 ,骨质疏松组较非骨质疏松组骨钙素 (BGP)、抗酒石酸酸性磷酸酶 (TRAP)、尿羟脯氨酸 (HOP) ,明显下降 (P<0 . 0 5)。结论 老年男性骨质疏松属于低转换型 。

Objective To measure the biochemical markers of bone resorption and formation in the different age groups of old men, and to observe the relationship between it and age, so as to study the clinical meaning of these bone biochemical markers in diagnosing primary osteoporosis type Ⅱ. MethodS Forearm bone mineral density was measured by dual energy X ray absorptiometry (DEXA); using full automatic biochemical analytic method to measure serum Alkaline phosphatase, urinary calcium (Ca), creatinine (Cr); using RIA to measure Osteocalcin (BGP), Tartrate Resistant Acid Phosphatase (TRAP), Hydroxyprolin (Hop). Ninety seven old men were divided into three groups, the results were compared with those of men under sixty years old, then they were divided into osteoporosis and non osteoporosis groups, compared their values. Results The biochemical markers of bone resorption and formation in the old men showed decrease with aging, while the bone metabolic makers such as serum BGP, TRAP and urinary HOP in osteoporosis group were also lower than those in non osteoporosis group ( P <0 05). Conclusions The osteoporosis of old men characterized as low turn over, the bone turn over marker showed decrease with aging.