摘要
36例原发性高血压患者(男21,女15,年龄50±SD 5yr;病程8±3yr)以纳多洛尔治疗,剂量40mg/d×1wk,以后根据血压及心率逐渐增量,8wk为一疗程,全组平均剂量为74±16mg/d,总有效率80％,其降血压的下降值,收缩压为3.30±0.20kPa,舒张压为2.20±0.20kPa(P<0.05)。其中15例并发心绞痛与12例并发房性早搏、房颤等心律失常亦大多缓解。全组血清肌酐较治疗前明显降低(P<0.05)。无严重不良反应。
Thirty six patients with essential hypertension (M 21, F 15; age 50+SD5yr; course of disease 8+3yr) were treated by oral administration of nadolol with mean dosage of 74+16mg/d for a course of 8wk. The decrease of blood pressure attained 3.30+0.20/2.20+0.20 kPa (P<0.05)with a 80% total effectiveness. Both complicating diseases of angina pectoris in 15 patients and arrhythmias in 12 patients were controlled with satisfaction. Serum creatinine level fell significantly (P<0.05). The adverse effecets (sinus bradycardia 2, dizziness 2, tired and anorexia 1) were self-relievable.
出处
《新药与临床》
CSCD
北大核心
1991年第1期11-14,共4页
关键词
纳多洛尔
高血压
心绞痛
nadolol/therapeutic use
hypertension/drug therapy
angina pectoris
