丁丙诺啡用于妇科术后镇痛

Analgesic activity of buprenorphine in gynecological postoperative pain

双盲试验40例随机分为4组,分别肌注丁丙诺啡0.3mg、0.15mg、哌替啶50mg和安慰剂;开放试验30例,只给予丁丙诺啡0.3mg。结果表明,两种设计的丁丙诺啡镇痛强度都明显高于安慰剂(P<0.01)。双盲法丁丙诺啡0.15mg具有和哌替啶50mg相同的镇痛作用,丁丙诺啡0.3mg则在给药3h后镇痛作用优于哌替啶(P<0.05);镇痛作用持续时间均超过6h。

Both double-blind and open clinical trials were conducted in 70 gynecologic postoperative patients to evaluate the analgesic activity of buprenorphine in comparison with those of pethidine and placebo. Forty patients were randomized into 4 groups with a dose of buprenorphine 0.3mg, 0.15mg, pethidine 50mg and placebo (5% glucose sol) given by im respectively in the double-blind clinical trail; the other 30 patients were selected for buprenorphine (0.3mg) in open clinical trial. Results showed that buprenorphine proved to be significantly (P<0.01) more effective than placebo in both clinical trials; buprenorphine 0.15mg achieved the same effect as pethidine 50mg, while buprenorphine 0.3mg was significantly (P<0.05) better than pethidine. Buprenorphine (0.3 mg) open clinical trial obtained the most pain relief among all of the groups. The duration of analgesia following buprenorphine appeared to last over 6 h. A similar frequency of nausea and vomiting were observed with both buprenorphine and pethidine, but neither serious side-effects nor abnormality of laboratory analyses were observed with either drug.