苯妥英钠与卡马西平在健康志愿者体内药物动力学相互作用

The pharmacokinetic interactions of phenytoin and carbamazepine in healthy Chinese volunteers

应用高效液相色谱法测定16名健康志愿者单用和联用苯妥英钠和卡马西平的血浓度。动力学过程用一房室模型一级动力学拟合。首次报道中国人体内苯妥英钠和卡马西平相互作用引起的2药最大稳态浓度C_((ss)max),最小稳态浓度C_((ss)min),达峰时间T_(max),消除半衰期T_(1/2),药时曲线下面积AUC等动力学参数变化的资料。结果表明苯妥英钠使卡马西平的T_(1/2)明显缩短,而卡马西平则延长苯妥英钠的T_(1/2)。

The pharmacokinetic interactions between phenytoin (PHT) and car-bamazepine (CBZ) were studied with HPLC in 16 healthy volunteers by taking PHT or CBZ and then both. The kinetic courses were described by an open one-compartment model and first-order elimination. Thus, the pharmacokinetic parameters C(ss)max C(ss)min, Tmax, T and AUC under the interactions between PHT and CBZ in healthy Chinese volunteers were obtained. The results indicated that PHT made T of CBZ shorter significantly but CBZ prolonged T of PHT.