尼可地尔、普萘洛尔和地尔硫治疗心绞痛的血流动力学

Hemodynamics of nicorandil, propranolol and diltiazem during treatment of angina pectoris

31例(男24,女7;年龄55±11yr)慢性稳定型心绞痛患者分4组,其中10例口服尼可地尔30mg,bid;7例口服普萘洛尔80mg,bid和9例口服地尔硫(艹卓)120mg,bid;5例为口服安慰剂组。并于首次服药后2h及持续服药2wk后进行踏车运动试验,观察比较药物对心绞痛患者休息或运动峰时的血流动力学变化。发现3种药物都能延长运动时间,延长心电图ST段呈缺血性压低1mm所需时间和心绞痛发作时间。

Thirty one patients (M 24, F 7; age 55±11yr) with chronic stable angina pectoris were given po nicorandil (30mg, bid, 10 patients), propranolol (80mg, bid, 7 patients), diltiazem(120mg, bid, 9 patients), or placebo (5 patients). Treadmill exercise test was performed before and after medication. These drugs showed a tendency to reduce the blood pressure and heart rate, to increase the exercise duration, the time of onset of angina, and the time of 1 mm ST depression in ECG at rest and during exercise.