HBO对豚鼠实验性牙周炎和牙龈血流量的影响

Effects of HBO on Experimental Periodontitis and Gingival Blood Flows in Animal

目的 探讨HBO对动物牙周炎和牙龈血流量（GBF）的影响及疗效维持时间。方法 用丝线缝扎加喂含10％糖的食料,形成实验性牙周炎,每日1次用0.25MPa HBO暴露60min,连续2周,观察治疗结束当时（10周）和结束后1月（14周）各牙周指标,并用激光多普勒血流仪测定GBF。结果HBO组在10周和14周时牙龈指数（GI）、菌斑指数（PLI）比牙周炎组明显降低（P<0.01）,牙周袋深度（PD）、牙周附着丧失（AL）、牙松动度（TO）比牙周炎组轻度降低（P<0.05）,10周时GBF比牙周炎组明显增加。14周时各牙周指标和GBF与10周时数值接近（P>0.05）。结论 HBO治疗后牙周各临床指标均降低,对GI和PLI作用最强,对PD、AL和TO有一定作用,治疗后GBF明显增加,并维持1月以上。

Objective To Study the effects of HBO on periodontitis and gingival blood flows(GBF) in animal. Methods Periodontitis was formed with silk thread sutured and high content sugar diet. For HBO therapy, the animals were exposed to a pressure of 0.25MPa(2.5ATA), breathing pure oxygen one session a day for 60min. The animals totally received 2 weeks treatment sessions. The periodontal clinical indices, including GI, PLI, PD, AL, tooth odontoseisis(TO), and GBF were recorded in the time of therapeutic stop (week 10) and 1 month after therapeutic stop (week 14). Results Assessment of GI and PLI indicated that more statistically significant differences were found in group HBO in week 10 and week 14 when compared with group periodontitis(P < 0.01), and significant differences could be discovered of PD, AL and TO whena comparison was made between group HBO and group periodontitis ( P < 0.05). More significant increase could be seen in GBF of group HBO than in group periodontitis in week 10, but no significant differences were observed in GI, PLI, PD, AL, TO and GBF between week 10 and week 14(P > 0.05). Conclusion The periodontal clinical indices and GBF in animal markedly decreased after HBO therapy, and the therapeutic effects could last more than 1 month.