原发性肝癌立体定向适形放射治疗临床研究

Clinical study of 3-dimensional conformal radiotherapy on primary liver cancer.

探讨立体定向适形放疗在肝癌治疗中的价值。应用 6MVX线直线加速器对 79例中晚期肝癌行适形性放疗。肿瘤靶体积 (GTV)平均 336 4cm3 ,计划靶体积 (PTV)平均 416 5cm3 。单次靶区处方剂量 2Gy～ 10Gy ,隔日一次。总照射剂量平均 38Gy。近期疗效CR 2 4 1%(19/79) ,PR48 1%(38/79) ,NR2 7 8%(2 2 /79) ,总有效率 (CR+PR)为 72 2 %。 1、2、3年生存率分别为 72 1%(5 7/79)、45 9%(2 8/6 1)和 2 0 0 %(8/4 0 )。放射性肝炎发生率为6 3%(5 /79)。立体定向适形放疗对肝癌具有较好的疗效 ,是一种较好的治疗模式。

To evaluate the treatment of 3-dimensional conformal radiotherapy (3-DCRT) on primary liver cancer, 79 patients with intermediate and advanced stages liver cancer were treated by 3-DCRT using 6MV X-ray. The mean value of gross target volume (GTV) was 336.4cm 3,and the mean value of planning target volume (PTV) was 416.5cm 3. All patients were given 2Gy～10Gy dose per single target volume, interval 1 day. The mean value of total dose was 38 Gy. Recent retraction rates was CR 24.1%(19/79),PR48.1%(39/79),NR27.8%(22/79),the rate of total validity was (CR+PR) 72.2%. The survival rates at 1?2 and 3 year were 72.1% (57/79), 45.9%(28/61) and 20.0%(8/40),radiohepatitis incidence was 6.3%(6/79). 3-Dimensional conformal radiotherapy has good treatment effect on hepatocarcinoma, which is a good treatmant pattern.