老年机械通气患者痰铜绿假单胞菌耐药分析

DRUG-RESISTANT ANALYSIS OF PSEUDOMONAS AERUGINOSA IN PATIENTS WITH MECHANICAL VENTILATION

分析机械通气患者痰铜绿假单胞菌对抗生素耐药情况。气管切开患者铜绿假单胞菌的耐药率比气管插管患者有所增加 ,其中阿米卡星、环丙沙星、磺苄西林、替卡西林耐药率增加有统计学意义 (P <0 0 5或 0 0 1) ;气管切开不同时间痰培养的铜绿假单胞菌对抗生素耐药率改变无统计学意义 ;1996～ 2 0 0 0年铜绿假单胞菌对氨曲南、头孢噻肟、环丙沙星、替卡西林、庆大霉素、哌拉西林、头孢哌酮的耐药率与 1991～1995年相比显著增加 ;铜绿假单胞菌对头孢他啶及亚胺培南耐药多年来一直保持稳定。

To analyze drug resistance of pseudomonas aeruginosa in patients with mechanical ventilation, drug resistance of pseudomonas aeruginosa in patients with tracheal incision was increased, compared with tracheal cannula. The drug resistance to amikacin, ciprofloxacin, meziocillin, ticarcillin was significantly increased( P <0 05, P <0 01). No statistical change in drug resistance of pseudomonas aeruginosa was found in patients with tracheal incision of different time; drug resistance to pseudomonas aeruginosa to aztreonam, cefotazime, ciprofloxacin, ticarcillin, gentamicin, piperacillin, cefoperazone was significantly increased in 1996～2000 compared with 1991～1995; Drug resistance of pseudomonas aeruginosa to ceftazidme and impenem was not changed.