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戊四氮所致慢性癫癎大鼠海马神经元选择性凋亡的研究 被引量：3

Selective Neuron Apoptosis in Hippocampus of Epileptic Rats Induced by Pentylenetetrazol
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摘要 目的 :探讨选择性凋亡在戊四氮所致慢性癫疒间形成中的作用。方法 :采用免疫组化及原位末端标记双标技术观察海马γ 氨基丁酸 (GABA)能神经元、谷氨酸 (Glu)能神经元各自凋亡情况。结果 :GABA能神经元凋亡数明显高于Glu能神经元凋亡数 ,两者比较有显著性差异。结论 :在癫形成期间脑内可能通过某种机制引发了细胞程序性死亡过程 ,选择性地引起GABA能神经元凋亡占优势 ,打破了兴奋与抑制性神经递质之间的平衡 。 Aim:To explore the role of selective neuron apoptosis in the pathogenesis of chronic epilepsy induced by pentylenetetrazol.Methods:The selective apoptosis of neurons in hippocampus of epileptic rats was observed by using double staining(immunohistochemistry and terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling)methods.Results:The amount of apoptosis of GABA ergic neuron was much higher than that of Glu ergic neuron.Conclusion:The balance of GABA ergic and Glu ergic neurons regulated by programmed cell death may be related to the pathogenesis of chronic epilepsy induced by pentylenetetrazol.
作者 何小华 王伟 阮旭中 王玉
机构地区 华中科技大学同济医学院附属同济医院神经内科
出处 《中国临床神经科学》 2002年第2期115-118,共4页 Chinese Journal of Clinical Neurosciences
基金 国家自然科学基金重点资助项目 (No:390 0 0 4 7)
关键词 慢性癫痫 大鼠 海马神经元 选择性凋亡 GABA能神经元 Glu能神经元 戊四氮 epilepsy apoptosis GABA ergic neuron Glu ergic neuron pentylenetetrazol
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献10

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同被引文献32

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中国临床神经科学
2002年 第2期

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