聚膦腈共混膜在动物体内的降解和组织相容性

In Vivo Degradation and Tissue Compatibility of Polyphosphazene Blend Films

研究了聚膦腈 /聚酯或聚酸酐共混膜 (PGP/ PL GA或 PGP/ PSTP)在小鼠体内的降解行为和组织相容性。初步结果表明 ,共混物的降解速率随共混组成的变化而变化 ,PGP/ PL GA(70∶ 30质量比 )降解 5 5 d重量损失6 8.4 % ,PGP/ PSTP(70∶ 30质量比 ) 12 d即降解 88.5 % ;PGP/ PL GA的降解机制包括水解和酶解 ,PGP/ PSTP主要是水解 ;PGP/ PL GA的组织相容性较 PGP/ PSTP更好 ,而且在 PGP/ PSTP体系中 PGP含量的增加有利于共混物组织相容性的改善。这些结果提示该共混物在医药领域具有潜在的应用前景。

The degradation performance and tissue compatibility of polyphosphazene/polyester or polyanhydride (PGP/PLGA or PGP/PSTP) blend films were investigated in mice. The results showed that the blend degradation rate could be regulated by adjusting PLGA or PSTP content in the blends. For example, the weight loss of PGP/PLGA (70:30 by wt) film was 68.4% after 55 days, whereas that of PGP/PSTP (70:30 by wt) was 88.5% only after 12 days. Also the mechanisms for in vivo degradation of blends of PGP/PLGA and PGP/PSTP were hydrolysed enzymatically and non enzymatically, respectively. The tissue compatibility of PGP/PLGA was better than that of PGP/PSTP, and an increase of the percentage of PGP in PGP/PSTP blends would help improve the tissue compatibility. These findings suggested that polyphosphazene blends be potential materials applied in medical field.