摘要
胸腺切除术是治疗重症肌无力的主要方法之一。 75 %的重症肌无力患者伴有胸腺异常 ,增生胸腺存在AChR特异反应性T、B细胞 ,胸腺瘤中存在着T细胞的分化 ,有乙酰胆碱受体抗体 (AChRAb)滴度升高。Tx可能去除了胸腺中导致B细胞活化的TH 细胞 ,其相关的细胞因子也逐步下调 ,AChRAb逐步减少 。
Thymectomy is one of the main methods in the management of myasthenia gravis. 75%of patients with myasthenia gravis have disorders in their thymus glands. There are specific response of T and B cells to AChR in hyperplasia thymus and differentiation of T cells with higher titer of AChRAb in thymoma. Thymectomy probably deletes helper T cells in thymus which activate B cells, cytokines associated with helper T cells .Titer of AChRAb drops. The symptom of myasthenia gravis remit.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2002年第B06期221-223,共3页
Immunological Journal
