粘附分子P选择素在大肠癌的表达及其意义

Expression and significance of anhesion molecule P-selectin in colorectal carcinoma

目的 研究细胞粘附分子P选择素在大肠癌组织中的表达及其与肿瘤转移和患者预后的关系。 方法 应用免疫组织化学催化信号放大法 (catalyzedsignalamplification ,CSA)观察了 90例大肠癌和 3 0例远离癌组织的正常大肠粘膜P选择素的表达 ,并对 5 3例大肠癌患者进行了随访。 结果 90例大肠癌中 5 8例阳性 ,阳性染色率为 64 4%。DukesA期、B期和C期的P选择素阳性染色率分别为 2 7 3 %、46 4%和 82 4%。 5 3例随访结果表明 ,P选择素阳性表达者平均生存期为 (2 8 1± 2 0 3 )个月 ,其 5年生存率为 40 0 % ;而阴性者平均生存率为 94 4% (P <0 0 5 )。

Objective To investigate the expression level of cell adhesion molecule P selectin in colorectal carcinoma and its relations with metastasis and prognosis. Methods P selectin expression in colorectal carcinoma(n=90) and remote normal mucosa(n=30)was detected with microwave LSAB immunohisochemical technique.Fifty three patients were followed up for more than 5 years. Results The positive expression of P selectin was observed in 58 of 90 patients with colorectal carcinoma(64 4%).The rates of P selevtin expression were 27 3% in patients with Dukes A stage,46 4% for Dukes B,and 82 4% for Dukes C respectively.The statistical analysis showed that the survival period and five year survival rate were lower in P selectin expression positive carcinomas(40 4%)than those in negative ones(94 4%,P<0 05). Conclusions P selectin expression in colorectal carcinomal was related to tumor metastasis and prognosis of patients.