NVB加DDP联合放疗同步与序贯治疗晚期NSCLC的临床研究

Synchronous and sequential chemo-radiotherapy with Navelbine plus Cisplatin in Locally advanced NSCLC

目的 :评价和比较NVB和放疗同步与序贯治疗局部晚期NSCLC近期疗效和患者耐受性。方法 :41例晚期NSCLC患者随机分入同步治疗组和序贯治疗组。同步组每周前 3日放疗前予NVB加DDP化疗 ,共 6周。序贯组予 2周期NP方案 (NVB 2 5mg/m2 ,d1、8,DDP5 0mg ,d1- 3)化疗后常规放疗。结果 :同步组和序贯组总有效率分别为 6 6 7%和 5 0 %,差异无显著性。同步组局部控制率高于序贯组 (P <0 0 5 )。两组不良反应无显著性差异。结论 :NVB加DDP和放疗同步治疗晚期NSCLC局部控制率高于序贯治疗 ,总有效率及不良反应两组相近。

Objective:To study the response and tolerance to concomitant and sequential chemo-radiotherapy with NVB plus DDP in locally advanced NSCLC.Methods:41 patients with advanced NSCLC were divided into synchronous group and sequential group randomly.Synchronous group:21 patients received conventional radiotherapy daily,before radiotherapy NVB and DDP was given for 3 days a week,totally 6 weeks.Sequential group:20 patients received radiotherapy as same as synchronous group after a cycles chemotherapy with NP regimen(NVB 25 mg/m 2,d1,8,DDP 50 mg,d1-3).Results:The effective rates of synchronous and sequential group was 66.7% and 50%,respectively (P>0.05).The local control rate of synchronous group was significantly higher than sequential group (P<0.05).There was no significant difference between two groups in the side effects.Conclusion:Concommtant and sequential chemoradiotherapy with NVB plus DDP has similar effective rate and side effects rates,while synchronous treatment has a higher local control rates.