高压氧对周围神经再生作用的实验研究

EXPERIMENTAL STUDY OF THE EFFECT OF HYPERBARIC OXYGENATION ON REGENERATION OF PERIPHERAL NERVE

本实验用大白鼠80只,实验组、对照组各40只。经异戊巴比妥钠腹腔麻醉,钳夹右坐骨神经致挫伤后,实验组即行高压氧治疗,对照组不予治疗。于钳夹术后2～8周观察,发现高压氧治疗组神经功能和小腿肌对电反应的恢复均提前;神经水肿较经,水肿液较少;雪旺氏细胞增生明显,髓鞘恢复较快;神经轴索再生数和再生率显著高于对照组。

Forty white rats, randomly equally divided into experimental and control groups, were used in this study. Sodium amytal was injected intraperitoneally, a crushing injury of the sciatic nerve was created in all of the 80 rats. The forty rats in the experimental group were treated with hyperbaric oxygenation while those rats in the control group received no treatement. From 2-8 weeks following the crushing injury of the sciatic nerves, it was observed that the treatment group showed an earlier recovery of nerve function and earlier response of leg muscles to electristimulation; less edema and exudation; marked proliferation of Schwann's cells and more rapid recovery of neurilemma, lastly, the number and rate of regeneration of neural axons were higher than that the control group.