脑卒中患者血浆细胞粘附分子及其相关因素测定的临床意义

The changes and clininal significances of adhesive molecule and relative factors in patiens with stroke

目的 探讨缺血性脑卒中患者外周血粘附分子及相关因素的变化及临床意义。方法 分别对脑卒中患者 (脑血栓 3 0例、脑出血 2 1例 )及健康者 3 0例外周血的可溶性细胞间粘附分子 1(sICAM 1)、可溶性血管粘附分子 1(sVCAM 1)、血小板第 4因子 (PF4)和D 二聚体 (D D)进行检测。结果 脑血栓组发病 2 4h及发病 1周时血的sICAM 1、sVCAM 1和PF4均明显高于对照组 (P <0 .0 1) ;脑血栓组发病 2 4h以上各指标高于脑出血组 (P <0 .0 1) ;且发病 2 4h及 1周血sICAM 1、sVCAM 1和PF4均有相关性 (P <0 .0 1)。结论 缺血性脑卒中患者从发病初期到发病 1周sICAM 1、sVCAM 1表达增强 ,血小板活性增强 ,为缺血性脑卒中发病早期使用抗粘附分子抗体及药物治疗提供临床试验依据。

Objective To explore the changes and clininal signifcances of abhesive molecule and relative factors in patients with acute cerebral infarction(ACI).Methods Serum sICAM 1?sVCAM 1?D D and PF4 were tested in 23 ACI patients,21 cerebral hemorrhage patients and 30 healthy subjects.Results The levels of serum sICAM 1?sVCAM 1 and PF4 in ACI group with in 24 hour and one week were higher than that in patients of control group  (P<0.01). The levels of serum sICAM 1?sVCAM 1 and PF4 in ACI group with in 24 hour higher than that in cerebral hemorrhage group(P<0.01).sICAM 1?sVCAM 1 had positive correlation with PF4 in 24 hour and one week (P<0.01).Conclusion The levels of serum sICAM 1?sVCAM 1 and PF4 increased continually from the onset to the first week in ACI,which took part in imflamation progress of cerebral cells damage.The use of antiadhesion molecular antibody and drugs may prevent or relief the process.