突出腰椎间盘组织中巨噬细胞的表达及意义

Presence and Clinical Significance of Macrophage in Herniated Lumbar Disc Tissue

目的 通过对突出腰椎间盘组织中巨噬细胞浸润的检测 ,进一步探讨腰椎间盘突出症的致痛机制。方法 38例标本取自不同类型的腰椎间盘突出症患者 ,患者术前术后记录疼痛等级。采用免疫组化SABC法对标本进行CD6 8(为单核 /巨噬细胞的表面标记 )染色。将组织学观察结果与患者术前及术后的疼痛量化结果进行比较。结果 ① 38例标本中CD6 8的阳性表达为2 2例 (5 7% ) ,其中 18例脱出及游离型椎间盘标本中阳性为 14例 (78% ) ,2 0例膨出及突出型中为 8例 (40 % )。②椎间盘组织中的巨噬细胞浸润与患者疼痛有相关性。结论 突出的椎间盘组织中存在着巨噬细胞 。

Objective To determine the macrophage imfiltration in the herniated disc tissue and explore the mechanism of lumber pain.Methods Thirty-eight specimens of various herniated disc tissue were studied immunohistogically with CD68.The outcome of histologic were compared with the pain grading scale.Result ①Macrophage was found in 22 of 38(57%)herniated lumber disc tissue;②A statistically significant correlation was found between the macrophage infiltration and the pain grading scale.Conclusion Macrophage infiltration is the pathogenesis of pain in lumber disc hernations.