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人免疫缺陷病毒-1整合酶及其抑制剂的研究进展 被引量:6

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摘要 整合酶 (integrase)对于人免疫缺陷病毒 (HIV) 1逆转录病毒的复制来说是必不可少的 ,因而成为抗艾滋病 (AIDS)药物设计的一个理性的靶点。最近文献报道了大量具有抗整合酶活性的化合物 。
作者 肖苏龙
出处 《国外医学(药学分册)》 2002年第3期157-161,共5页 Foreign Medical Sciences(Section of Pharmarcy)
基金 北京市自然科学基金资助项目 (70 12 0 18) 北京大学创建一流大学基金项目 (985 ) 北京大学生物医学跨学科研究中心项目
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参考文献18

  • 1Mazumder A, Neamati N, Ojwang JO, et al. Inhibition of the human immunodeficiency virus type Ⅰ integrase by guanosine quartet structures [J]. Biochemistry, 1996, 35(43): 13762 - 13771.
  • 2Jing N, Marchand C, Liu J, et al. Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in vitro [J]. J Biol Chem, 2000, 275(28):21460-21467.
  • 3Gottfredsson M, Bohjanen PR. Human immunodeficiency virus type Ⅰ as a target for gene therapy[J]. Front Biosci,1997, 2:619- 634.
  • 4d'Angelo J, Mouscadet JF, Desmaele D, et al. HIV-1 integrase: the next target for AIDS therapy[J]? Pathol Biol (Paris), 2001, 49(3) :237 - 246.
  • 5Patrick H, Jonathan L. Retroviral DNA integration [J].Microbiol Mol Biol Rev,1999,63(4):836-843.
  • 6张健慧.HIV整合酶研究进展[J].国外医学(病毒学分册),1998,5(3):79-83. 被引量:1
  • 7Joseph PG. Retroviral integrase: conserved sequence information as a guide to understanding structure and function of the retroviral and bacterial IS3 DD(35) E transposases [J]. J Mol Struct (Theochem), 1998, 423(1/2) :41 -57.
  • 8Bujacz G, Jaskolski M, Alexandratos J, et al. High-resolution structure of the catalytic domain of avian sarcoma virus integrase[J]. J Mol Biol, 1995, 253(2):333-346.
  • 9Pommier Y, Marchand C, Neamati N. Retroviral integrase inhibitors year 2000: update and perspectives[J]. Antiviral Res, 2000, 47(3): 139 - 148.
  • 10Neamati N, Sunder S, Pommier Y. Design and discovery of HIV-1 integrase inhibitors[J]. Ther Focus, 1997, 2(11):486 - 498.

同被引文献61

  • 1Chan D C, Fass D, Berger J M, et al. Core structure of gp41 from the HIV envelope glycoprotein[J]. Cell, 1997,B9: 263.
  • 2Jiang S, Lin K, Zhang L, et al. A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody[J]. J Virol Methods, 1999,80 : 85.
  • 3Debnath A K, Lin K, Jiang S. Structure-based identification of small molecule antiviraI compounds targeted to the gp41 core structure of the human immunodeficiency virus type 1 [J]. J Med Chem, 1999,42:3203.
  • 4Eckert D M, Malashkevich V N, Hong I. H, et al. Inhibiting HIV-1 Entry: Discovery of D-Peptide Inhibitors that Target the gp41 Coiled-Coil Pocket[J]. Cell, 1999,99 : 103.
  • 5Daria J, Hazuda P F, Wjtmer M,et al.Inhihitors of strand transfer that prevent integration and inhibit HIV-integase catalytic domain complexed with an inhibitorfa platform for antiviral drug design [J]. Proc Natl Acad Sci USA, 1999,96 : 13040.
  • 6King P J, Ma G, Miao W, et al. Structure-activity relationships; analogues of the dicaffeoylquenic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type-I integrase and replication [J]. J Med Chem, 1999,42,497.
  • 7Sasaki S,Fukushima J, Hamajima K,et al. Clin, Exp Immunol,1998,11(1):30.
  • 8.[EB/OL].中国爱滋病网 网址:http://www.aidscn.com.,.
  • 9高琦 王琳 赵知中.非肽类HIV蛋白酶抑制剂的研究进展[J].药学进展,2002,34(8):635-635.
  • 10.[EB/OL].三九健康网,网址:http://www.39.net.,.

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