4-(3-三氟甲基)苯基-4-哌啶醇的合成

Synthesis of 4-(3-trifuoromethyl) phenyl-4-piperidinol

以间溴三氟甲基苯、N-苄基 -4-哌啶酮为原料 ,经格氏反应、催化脱苄等步骤合成了医药中间体 4-(3 -三氟甲基 )苯基 -4-哌啶醇。总收率达 87.9% ,纯度达 99.0 % ,并得到元素分析。

Starting from 3 bromo trifluoromethylbenzene and N benzyl 4 piperidinone,4 (3 trifuoromethyl) phenyl 4 piperidinol was synthesized via Grignard reaction followed by catalyzed debenzylation.The total yield and purity were up to 87.9% and 99.0%,respectively.The product was identified by elementary analysis,IR and 1HNMR spectra.