2′,4′-二氟-4-羟基-(1,1′-联苯)-3-羧酸的制备

Preparation of diflunisal

以 2 ,4-二氟苯胺为起始原料 ,经联苯化作用、Friedel-Crafts酰化反应、Baeyer-Villiger重排、水解和羧基化作用 5步反应制得 2′,4′-二氟 -4-羟基 -(1 ,1′-联苯 ) -3 -羧酸 ,总收率可达 3 8.4%

Diflunisal was prepared from 2,4 difluoroaniline via biphenylation,Friedel Crafts acylation,Baeyer Villiger rearrangement,hydrolysis and carboxylation.The overall yield was 38.4%.