苄丙咯对结扎家兔冠状动脉造成实验性心肌梗塞的影响

THE EFFECT OF BEPRIDIL ON EXPERIMENTAL MYOCARDIAL INFARCTION CAUSED BY HIGH LEVEL DOUBLE LIGATION OF LEFT ANTERIOR DESCENDING CORONARY ARTERY IN RABBITS

本文利用结扎家兔冠状动脉左前降支(LAD)造成急性心肌梗塞模型,通过ECG观察其∑_(ST)、N_(ST)、N_(Q)及用N-BT大体标本染色法研究苄丙咯对结扎LAD后的影响。实验结果表明,LAD结扎48h内,苄丙咯和心得安能降低∑_(ST)、N_(ST)、N_(Q),ST段恢复至等电位线的时间提前。梗塞心肌占全心重量百分比减小。二者之间作用效果相似。

Through the observation of ∑sT, NST and NQ of ECG and N - BT staining, we studied the effect of bepridil on the experimental myocardil infarction induced by high level double ligation of the left anterior descending coronary artery in rabbits. It was demonstrated that in the groups treated with bepridii and propranoiol during the observation Period of 4g h, ∑ST, NST and NQ were decreased, the recovery of ST segment to isoelectric level was facilitated and the weight percentage of infarcted myocardium was decreased.The therapeutic efficiency of bepridil was found to be comparable to that of propranoiol.